曾钢

2017-06-19



曾钢,男,汉族,1969年4月生,山东人,美国洛杉矶加州大学UCLA医学院教授,1991年毕业于北京大学生物系,1996年获得美国弗吉尼亚理工大学(Virginia Tech)博士学位,1997年-2002年在美国国立癌症研究所(NCI)博士后师从肿瘤免疫治疗开拓者Steve Rosenberg教授。曾钢是肿瘤抗原NY-ESO-1共同发现者,并且在世界上首次发现NY-ESO-1在树突状细胞表面的受体系统,针对该抗原的多种免疫治疗已经进入美国二期临床。曾钢于2002年加入UCLA并独立主导肿瘤免疫诊断和免疫治疗实验室的工作,得到了美国国立癌症研究所(NCI),美国国防部(DOD),美国癌症协会(ACS),美国癌症预防基金会(Prevent Cancer Foundation)等顶级专业基金的支持。在此期间,他的研究发现产生了治疗性癌症疫苗系统eVAX和前列腺癌液相芯片新平台A+PSA检测技术。曾钢因此获得过UCLA的奥本海默奖,实验室转入市场奖,和美国国立癌症研究所成就证书。曾钢教授利用科研成果于2014年在洛杉矶成立T-Cure Bioscience公司,开发针对亚洲病人的TCR-T细胞治疗实体瘤新产品。

Dr. Zeng is Professor at the David Geffen School of Medicine at UCLA and an expert in cancer immunology and cancer biomarkers. Dr. Zeng completed his postdoctoral fellowship at the NCI with Dr. Steve Rosenberg, a pioneer in cancer immunotherapy.  At NCI, Dr. Zeng and his colleagues co-discovered the cancer/testis antigen NY-ESO-1, now the world’s leading target for vaccine and TCR-based immunotherapy. At the NCI, he also developed a “reverse immunology” approach to identify various NY-ESO-1 specific T cells and T cell epitopes, such as those restricted by HLA-DR1/4, HLA-DP4 and dual HLA-DP4/A2.  These discoveries gave rise to many investigator-initiated clinical trials in the field of cancer vaccines and adoptive T cell therapy at NCI, Roswell Park Cancer Institute, Baylor College of Medicine, Medizinische Klinik Krankenhaus Nordwest, and Fred Hutchinson Cancer Research Center.  Since his time at NCI, Dr. Zeng has devoted his career to studying the immunobiology of NY-ESO-1 and its clinical implications not only as a T cell target, but also as an immune adjuvant and a cancer biomarker.  After joining UCLA, he has led a research team accomplishing seminal works including the first discovery of dendritic cell-surface receptors for NY-ESO-1 and the development of the “A+PSA” assay. Dr. Zeng’s work has resulted in 10 US and international patents and has been recognized by more than 40 peer-reviewed publications as well as peer-reviewed grants from the U.S. Department of Defense, American Cancer Society and National Institutes of Health.  Dr. Zeng is a recipient of the Certificate of Achievement from NCI, and the Stein Oppenheimer award and Lab2Market award from UCLA in recognition for his scientific contributions. He holds a PhD in Biochemistry from Virginia Tech and a BS in Biology from Peking University.




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